Measurement of Cue-Induced Craving in Human Methamphetamine- Dependent Subjects;New Methodological Hopes for Reliable Assessment of Treatment Efficacy

* Corresponding Author: Zahra Alam Mehrjerdi, MA., Neurocognitive laboratory of Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences. Address: No.669, South Karegar Ave, Tehran, 1336616357, Iran, Tel/Fax +982155421177. Email: [email protected] Methamphetamine (MA) is a highly addictive psychostimulant drug with crucial impacts on individuals on various levels. Exposure to methamphetamineassociated cues in laboratory can elicit measureable craving and autonomic reactivity in most individuals with methamphetamine dependence and the cue reactivity can model how craving would result in continued drug seeking behaviors and relapse in real environments but study on this notion is still limited. In this brief article, the authors review studies on cue-induced craving in human methamphetaminedependent subjects in a laboratory-based approach. Craving for methamphetamine is elicited by a variety of methods in laboratory such as paraphernalia, verbal and visual cues and imaginary scripts. In this article, we review the studies applying different cues as main methods of craving incubation in laboratory settings. The brief reviewed literature provides strong evidence that craving for methamphetamine in laboratory conditions is significantly evoked by different cues. Cue-induced craving has important treatment and clinical implications for psychotherapists and clinicians when we consider the role of induced craving in evoking intense desire or urge to use methamphetamine after or during a period of successful craving prevention program. Elicited craving for methamphetamine in laboratory conditions is significantly influenced by methamphetamine-associated cues and results in rapid craving response toward methamphetamine use. This notion can be used as a main core for laboratory-based assessment of treatment efficacy for methamphetamine-dependent patients. In addition, the laboratory settings for studying craving can bridge the gap between somehow-non-reliable preclinical animal model studies and budget demanding randomized clinical trials. A B S T R A C T Article info: Received: 15 October 2010 First Revision: 1 November 2010 Accepted: 23 November 2010